sk channels — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9522	Rimtuzalcap	CAD-1883	Potassium Channel
	Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin...		Potassium Channel
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T20968	CyPPA		Potassium Channel , Dopamine Receptor
	CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.		Potassium Channel , Dopamine Receptor
T12256	NS8593 hydrochloride	NS8593 HCl	Potassium Channel
	NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .		Potassium Channel
T16345	NS13001	N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine	Potassium Channel
	NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium ch...		Potassium Channel
TP1223L	Apamin acetate	Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel
	Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following lacera...		Potassium Channel
T24547	NS4591	NS 4591,NS-4591
	NS4591 is a modulator of SK-IK channels.
T80170	Tamapin		Potassium Channel
	Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (SK) channels, particularily SK2 (Potassium Channel). It inh...		Potassium Channel
T70224	Bupivacaine tartrate
	Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intra...
T80171	Tamapin TFA		Potassium Channel
	Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated K(+) (SK) channels, particularly the SK2 subtype (Potassium C...		Potassium Channel
TP1223	Apamin	Apamine
	Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic acti...
T76184	Scyllatoxin
	Scyllatoxin (Leiurotoxin I), a peptide toxin derived from the venom of the scorpion (Leiurus quinquestriatus hebraeus), acts as a blocker of small-conductance K Ca (SK) channels. It notably enhances the release of norepi...
T39963	AP14145 hydrochloride
	AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is h...
TP1222	Apamin TFA (24345-16-2 free base)	Apamin TFA,Apamine TFA
	Apamin TFA (Apamine TFA) is a toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3.
T75746	Apamin TFA
	Apamin TFA, also known as Apamine TFA, is an 18-amino acid peptide neurotoxin derived from apitoxin (bee venom). It functions as a specifically selective blocker of Ca2+-activated K+ (SK) channels and demonstrates anti-i...